武警医学2012，Vol.23Issue(2)：130-132,3.
不同结构萜类对盐酸普萘洛尔透皮活化能的影响
Effect of terpenes of different structure on transdermal activation energy of propranolol hydrochloride
段姚尧 1陈莉 2冯欲静 2崔颖3
作者信息
- 1. 300162,天津,武警后勤学院科研部
- 2. 300162,天津,武警后勤学院药剂学教研室
- 3. 300162,天津,武警后勤学院药物化学教研室
- 折叠
摘要
Abstract
Objective To investigate the effect of terpenes of different structure on the transdermal activation energy of prop-ranolol hydrochloride. Methods The permeability coefficients of propranolol hydrochloride through the rat skin were determined in vitro at different temperatures and the transdermal activation energy was calculated from Arrhenius relationship. Results The Arrhe-nius equations under different conditions were calculated, in which there was good coefficient relationship (r > 0. 97) between the varieties. The transdermal activation energy of propranolol hydrochloride calculated from the slope of Arrhenius equations was 90. 06 Kj/mol in the control solution, 69.42 Kj/mol in menthol solution, 106. 14 Kj/mol in menthone solution, and 124.39 Kj/mol in bisabolol solution. Conclusions A strong transdermal activation energy of propranolol hydrochloride is required to pass through the rat skin. Terpenes except menthol cannot decrease the energy significantly. 1 he possible mechanism might be the formation of molecular hrdrogen bonds between propranolol hydrochloride and terpenes.关键词
盐酸普萘洛尔/萜类/透皮活化能Key words
propranolol hydrochloride/ terpenes/ transdermal activation energy分类
医药卫生引用本文复制引用
段姚尧,陈莉,冯欲静,崔颖..不同结构萜类对盐酸普萘洛尔透皮活化能的影响[J].武警医学,2012,23(2):130-132,3.
