外科理论与实践2012，Vol.17Issue(1)：25-28,4.
IL-1α和IL-1β在胃癌组织中的表达及其临床意义
Interleukin-1α and interleukin-1β in gastric cancer tissue and its clinical significance
李洁 1李建芳 1苏丽萍 1刘炳亚1
作者信息
- 1. 上海交通大学医学院附属瑞金医院外科 上海消化外科研究所上海市胃肿瘤重点实验室,上海 200025
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摘要
Abstract
Objective To investigate the association between the expression of interleukin (IL)-lα, IL-lβ and the clinicopathologic parameters in gastric cancer, and to evaluate the significance of IL-lα and IL-1β in the development of gastric cancer. Methods Primary gastric tumor tissues and their corresponding adjacent nontumor tissues (5 5 cm away from the tumor) were collected from 73 patients with gastric cancer. The total protein was extracted by RIPA lysis buffer and protein concentration was determined by BCA method. Expressions of IL-lα and IL-1β in gastric cancer were measured by enzyme-linked immunosorbent assay. The association between relative levels of cytokines and clinicopathological characteristics was analyzed. Results The median level of IL-lα in gastric tissue was higher than that in adjacent nontumor tissue [(3.450 vs 2.665) ng/g protein, P＜0.01], and it was upregulated with the increase of tumor size and the depth of invasion [(4.549 vs 2.629), (2.659 vs 3.450) ng/g protein, P＜0.05]. Although no difference of the IL-1β level existed between tumor tissues and adjacent nontumor tissues, IL-1β levels were upregulated with the increase of tumor size [(4.202 vs 2.930) ng/g protein, P＜0.05]. Conclusions Our results suggest that inflammatory cytokine IL-lα and IL -1β play important roles in the development of gastric cancer.关键词
胃癌/白细胞介素-1α/白细胞介素-1βKey words
Gastric cancer/Interleukin-lα/Interleukin- 1β分类
医药卫生引用本文复制引用
李洁,李建芳,苏丽萍,刘炳亚..IL-1α和IL-1β在胃癌组织中的表达及其临床意义[J].外科理论与实践,2012,17(1):25-28,4.
