物理化学学报2011，Vol.27Issue(11)：2682-2690,9.
竹红菌乙素镁、锌配位聚合物的光物理和光生物性质
Photophysical and Photobiological Properties of Coordination Polymers of Hypocrellin B Complexes Containing Magnesium and Zinc
摘要
Abstract
Hypocrellin B (HB) can chelate with Mg2* and Zn2* ions to form the coordination complexes Mg2*-HB and Zn2*-HB, which consist of 5-22 repeat units. The structures of these two complexes are characterized by ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and 1H nuclear magnetic resonance (1H NMR). The relative quantum yields of singlet oxygen (1O2) for Mg2*-HB and Zn2*-HB are 1.2 and 0.42 times as high as that of HB, respectively. Transient absorption spectra results indicate that O2 is able to quench the triplet excited state of Mg2*-HB and Zn2*-HB with an efficiency higher than 96%. The intersystem crossing efficiency (0T) and the fraction of triplet states quenched by O2 that yield 1Os (fl) are considered to be essential for the singlet oxygen quantum yields of HB and its complexes. Electron paramagnetic resonance (EPR) results suggest that Mg2*-HB and Zn2*-HB have a weak ability to generate a semiquinone anion radical, which reduces the generation of the superoxide anion radical (O I~) by Mg2 *-HB and Zn2 *-HB. The results of the UV-Vis spectra and the deoxyribonucleic acid (DNA) melting temperature experiments indicate that Mg2*-HB and Zn2*-HB bindwith calf thymus (CT) DNA in an electrostatic interaction mode. Under aerobic conditions, the efficiencies of photoinduced damage to CT DNA by Mg2*-HB, HB, and Zn2*-HB are found to be 32%, 25%, and 22%, respectively. The reactive oxygen quencher experiments indicate that singlet oxygen is the main component generated by Mgz*-HB that damages CT DNA.关键词
竹红菌乙素/配位聚合物/单重态氧/超氧负离子自由基/DNA光损伤Key words
Hypocrellin B/ Coordination polymer/ Singlet oxygen/ Superoxide anion radical/ DNA photodamage分类
化学化工引用本文复制引用
郭创龙,欧植泽,高云燕,王中丽,金和林,李海霞..竹红菌乙素镁、锌配位聚合物的光物理和光生物性质[J].物理化学学报,2011,27(11):2682-2690,9.基金项目
国家自然科学基金(21073143),教育部"春晖计划"基金(Z2009-1-71002,Z2009-1-71006)和西北工业大学基础研究基金(JC200822,JC20100239)资助项目 （21073143）
