西安交通大学学报（医学版）2012，Vol.33Issue(1)：53-55,60,4.
超声观测高同型半胱氨酸血症兔内皮功能损伤与血管细胞粘附分子的关系
Relationship between endothelium-dependent dilation observed with high resolution ultrasound and VCAM-1 of plasma in hyperhomocysteinemia rabbits
阮骊韬 1张近 1常小妮 1赵巧玲 1杨锦茹 1任晓萍 1魏炜 1宋艳1
作者信息
- 1. 西安交通大学医学院第一附属医院超声科,陕西西安710061
- 折叠
摘要
Abstract
Objective To study the relationship of vascular cell adhesion molecule-1 (VCAM-1) and nitric oxide (NO) with endothelium-dependent dilation (EDD) in hyperhomocysteinemia (Hhcy) rabbits so as to reveal the mechanism of endothelial dysfunction. Methods Twenty-two New Zealand rabbits were randomized into two groups (11 in each group). Normal control group received normal diet while methioine group received methioine-rich diet which consisted of L-methioine 0. 8 g/(kg ? D). Then NO and VCAM-lin plasma and EDD were examined at 0, 20, 40, 60 and 80 days, respectively. Results ? In hyperhomocysteinemia rabbits, compared with thaf in normal control group, EDD of external iliac artery in methioine group was reduced significantly in the time-dependent manner [at day 80, ( -1.74±3.58)% vs. Day 0 (13.43 + 4. 13)%, P<0.01]. ? At the same time, compared with that in normal control group, NO in methioine group was reduced in the time-dependent manner [at day 80, (217. 43 ± 27. 38) /umol/L vs. Day 0 (379. 75 + 56. 83) f^mol/L, P<0.05] and VCAM-1 was increased significantly in the time-dependent manner [at day 80, (0.091 2 + 0.009 7)ng/mL vs. Day 0 (0.047 2 + 0.004 7)ng/ mL, P<0.01]. Conclusion There is a significant relationship between EDD, detected precisely by high-resolution ultrasound, and VCAM-1 in hyperhomocysteinemia rabbits. Endothelial dysfunction induced by Hey is a multi-path process.关键词
同型半胱氨酸/血管细胞粘附分子-1/一氧化氮/内皮依赖性舒张功能/超声检查Key words
homocysteine/ vascular cell adhesion molecule-1 (VCAM-1)/ nitric oxide/ endothelium dependent dilation/ ultrasonography分类
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阮骊韬,张近,常小妮,赵巧玲,杨锦茹,任晓萍,魏炜,宋艳..超声观测高同型半胱氨酸血症兔内皮功能损伤与血管细胞粘附分子的关系[J].西安交通大学学报（医学版）,2012,33(1):53-55,60,4.
