西安交通大学学报（医学版）2012，Vol.33Issue(1)：99-103,5.
Cox比例风险模型在原发性肝癌患者凝血功能分析中的应用
Application of Cox proportional hazard model in coagulation function analysis in patients with primary liver cancer
摘要
Abstract
Objective To explore the association of clinical staging and survival with coagulation parameters in patients with primary liver cancer by using Cox proportional hazard model so as to provide a parameter for clinical management and prognosis. Methods Coagulation parameters were evaluated in 228 patients with primary liver cancer, 52 patients with common liver diseases and 52 healthy controls. The relationship between primary liver cancer staging and coagulation parameters was analyzed; follow-up examinations were performed. The Cox proportional hazard model was used to analyze the relationship between coagulation parameters and survival. Results The changes of coagulation parameters in the patients with primary liver cancer were significantly different from those in the normal controls. The effect of the disease on coagulation function became more obvious as the severity of liver cancer increased (P<0.05). The levels of D-dimer, fibrinogen degradation products (FDP), fibrinogen (FIB) and platelets (PLT) were negatively correlated with the long-term survival of patients with advanced liver cancer. Conclusion Coagulation parameters can timely and accurately reflect the lesion and risk extent in liver cancer patients. Dynamic monitoring of coagulation parameters may help ensure better surveillance and treatment for liver cancer patients.关键词
Cox比例风险模型/凝血功能/原发性肝癌/肝癌分期Key words
Cox proportional hazard model/ coagulation function/ primary liver cancer/ liver cancer staging分类
医药卫生引用本文复制引用
丁丽,郭炫,赵珊,王跃飞,康钦炯,刘懿..Cox比例风险模型在原发性肝癌患者凝血功能分析中的应用[J].西安交通大学学报（医学版）,2012,33(1):99-103,5.基金项目
陕西省科技攻关项目(No.2009K01-78) （No.2009K01-78）
