现代妇产科进展2011，Vol.20Issue(12)：921-925,5.
妊娠期脂肪组织Omentin mRNA表达与胰岛素抵抗的相关性
Omentin mRNA expression in adipose tissue in pregnant women and their relationship with insulin resistance
摘要
Abstract
Objective; To investigate the changes of omentin mRNA expression in different parts of adipose tissue in gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) and the relationship between the omentin mRNA expression with insulin resistance. Methods;In a prospective study,43 women identified with GDM according to WHO criteria by a 2-h 75 g oral glucose tolerance test were compared with control group matched for age (± lyear), exact parity,body mass index(BMI), and gestational weeks at delivery(± 1 week). Abdominal subcutaneous (SA) and visceral adipose (VA) tissues were obtained during cesarean section. Real-time quantitative PCR was used to measure the omentin mRNA level in adipose tissues. The omentin mRNA expression in different parts of adipose tissue in two groups were e-valuated and the relationship between omentin mRNA expression and insulin resistance were analysed. Results; (1) In GDM omentin mRNA expression in both SA(0.057±0.014 vs 0.070 ±0.015,P<0.01)and VA(0.560±0. 125 vs 0.713±0. 150, P<0. 01) were significantly lower than those in NGT. (2) By univariate analyses, HOMA-IR was found to be related with BMI atpre-pregnancy(r = 0. 406, P = 0. 001) and delivery (r = 0. 332, P = 0. 002), as well as with omentin mRNA expression in SA(r=-O. 277, P = 0.010)and VA(r=-0. 228,P = 0. 035) statistically. However, when further multiple stepwise regression analysis was used, only BMI at pre-pregnancy and omentin mRNA in VA were proved as independent predictors of HOMA-IR. Conclusions: The decrease of Omentin mRNA expression in visceral omental adipose tissue of GDM patients may be involved in the deterioration of IR during the late pregnancy.关键词
妊娠期糖尿病/脂肪组织/Omentin/胰岛素抵抗Key words
Gestational diabetes mellitus/ Adipose tissue/ Omentin/ Insulin resistance分类
医药卫生引用本文复制引用
陈卓,马润玫,胡大春,邵剑春,劳子僖,田玉芹..妊娠期脂肪组织Omentin mRNA表达与胰岛素抵抗的相关性[J].现代妇产科进展,2011,20(12):921-925,5.基金项目
云南省自然科学基金资助项目(No:2007C135M) （No:2007C135M）
