现代妇产科进展2011，Vol.20Issue(12)：932-935,4.
子痫前期孕妇血清中氧化应激产物H2O2对sHLA-G表达的影响
Effect of hydrogen peroxide on sHLA-G expression at term in maternal circulation during preeclampsia
摘要
Abstract
Objective; To explore the effect of Hydrogen Peroxide (H2 O2) on Shla-G expression at term in maternal circulation during preeclampsia and the etiology of early-onset preeclampsia and later-onset preeclampsia. Methods: Blood sampling was collected from 15 women diagnosed early-onset preeclampsia, 15 women diagnosed later-onset preeclampsia and 15 healthy women(control group)at term. Levels of H2O2 in maternal serum from patients with preelampsia and normal pregnancy were identified upon colorimetry, and protein levels of Shla-G were evaluated by ELISA. The correlation between H2O2 and Shla-G was analysed. Results: (1)Compared with the controls,the concentration of serum H2O2 was higher in early-onset preeclampsia and later-onset preeclampsia (P<0. 05). The-concentration of serum H2O2 were higher in early-onset preeclampsia than later-onset preeclampsia(P<0. 05). (2) Compared with the controls,the expression of Shla-G was decreased in early-onset preeclampsia and later-onset preeclampsia serum (P<0. 05) . The expression of serum Shla-G was decreased in early-onset preeclampsia than later-onset preeclampsia. (3) There was an inverse correlation between HLA-G and H2O2 at term in the maternal serum(r = -O. 835, P<0. 05) . Conclusion:Oxidative stress is likely to provide a simplified,yet largely accurate,description of the origin of early-onset pre-eclampsia and H2O2 could down-regulate Shla-G expression in the maternal serum during pre-eclampsia.关键词
子痫前期/H2O2/可溶性HLA-GKey words
Preeclampsia/ Hydrogen peroxide/ Soluble human leukocyte antigen-G分类
医药卫生引用本文复制引用
周雪,殷茵,孙丽洲..子痫前期孕妇血清中氧化应激产物H2O2对sHLA-G表达的影响[J].现代妇产科进展,2011,20(12):932-935,4.基金项目
国家自然科学基金项目(No:81070511) （No:81070511）
江苏省自然科学基金项目(No:BK2010583) （No:BK2010583）
