现代妇产科进展2011，Vol.20Issue(12)：948-951,4.
卵泡液中雌孕激素水平及卵泡大小与卵母细胞成熟度的关系
The relationship among oocyte diameter, estrogen and progesterone levels in follicular fluid and the maturity of oocytes during intracytoplasmic sperm iniection and embrvo transfer cycle
毕媛 1高磊 1田琳 1于康 2邹淑花1
作者信息
- 1. 青岛市妇女儿童医疗保健中心生殖中心,青岛266012
- 2. 潍坊市人民医院生殖医学中心
- 折叠
摘要
Abstract
Objective;To discuss the relationship among the oocyte diameter,estrogen (E2)and progesterone(P) levels in the follieular fluid and development of oocytes on the oocyte retrieval day by intracytoplasmic sperm injection (ICSI) . Methods: Follieular fluid was obtained from 125 follicles of 51 women receiving ICSI treatment due to male problems. E2 and P concentrations were determined by chemiluminesence immunoassay (CLIA). The oocyte diameter was measured by B ultrasound. Analyze the relationship among the oocyte diameter, estrogen (E2) and progesterone(P) levels in the follieular fluid and development of oocytes on the oocyte retrieval day. Results;The oocyte diameter was positively correlated with the concentration of E2 (r = 0. 724, P<0. 05) and the concentration of P(r = 0. 798, P<0. 05). According to the oocyte maturity the samples were divided into M II group, M I group, GV group and degradation group. In degenerate group, E2 level was significantly lower than that in M E group(P<0. 05). There was no significant difference among the three groups(P>0.05). All the samples based on P/E2 ratio were divided into three groups: 1 (< 15), 2(15 -25), 3(>25). The results showed that the maturation rate was the highest in group 2 and it had statistically significant difference compared to group 1 and 3 (P<0.05) while there was no significant difference between group 1 and 3(P>0. 05). According to the average diameter of follicles the samples were divided intolarge(>1. 6cm), medium(1.6 ～ 1. 2cm) and small(<1. 2cm) groups. The maturation rate was the highest in large follicle group and it had statistically significant difference compared to medium and small group(P<0. 05). There was significant difference between medium and small group(P<0. 05). Conclusion: The oocyte diameter is positively correlated to the estrogen and progesterone levels in the follicular fluid. When P/E2 reaches 10 to 30 the oocyte maturation rate is higher. There is significant difference between large follicle group and medium/small group.关键词
卵胞浆内单精子显微注射/卵泡液/雌激素/孕激素/卵母细胞/成熟度/P/E2Key words
Intracytoplasmic sperm injection/ Follicular fluid/ Estrogen/ Progesterone/ Oocyte/ Maturation/ P/E2分类
医药卫生引用本文复制引用
毕媛,高磊,田琳,于康,邹淑花..卵泡液中雌孕激素水平及卵泡大小与卵母细胞成熟度的关系[J].现代妇产科进展,2011,20(12):948-951,4.
