中国组织工程研究2012，Vol.16Issue(1)：171-174,4.DOI:10.3969/j.issn.1673-8225.2012.01.037
脐血间充质干细胞移植脊髓损伤恢复期患者的免疫功能变化
Effect of umbilical cord blood mesenchymal stem cells transplantation on immune function of spinal cord injury patients
摘要
Abstract
BACKGROUND: Mesenchymal stem cells (MSCs) transplantation has certain immunogenicity. However, there was no in-depth and system reports about the effect of MSCs trans plantation on spinal cord injury patients immune function.OBJECT FVE: To observe the effects of umbilical cord blood M S Cs (U C B- MSCs) trans pla ntation on immune function of spinalcord injury (SC \) patients.METHODS: Sixty-one spinal cord injury (SCI) patients were treated by intervenous drop infusion and lumbar sub arachnoid spacepuncture to UCB-MSCs. Flowcytometry and immunoturbidimetry (ITM) were used to detect the content of T lymphocyticRESULTS AND CONCLUSION: Compare with pre-trare plantation, the content of CD3 + . IgA and IgG was decreased and the differences were significant The content of CD4+. CDS+. CD4+/CD8+. IgM. C3 and C4was also changed and the differences we renotsignificant. It indicates that UCB-MSCs transplantation could not activate the immunological response of cell and humoralimmunity,so the trans plantation is safety.Negative assorn modation is exist,but the relevant indicators need a furtherimprovement,expand samples,and clearly relevant mechanism.关键词
脐血源间充质干细胞/细胞移植/脊髓损伤/免疫功能/T淋巴细胞亚群/免疫球蛋白/补体分类
医药卫生引用本文复制引用
赵宁,杨万章,张敏,盛佑祥,唐映..脐血间充质干细胞移植脊髓损伤恢复期患者的免疫功能变化[J].中国组织工程研究,2012,16(1):171-174,4.基金项目
深圳市科技局资助(200405219),课题名称:间充质干细胞治疗神经系统疾病的临床研究. （200405219）
