中国组织工程研究2012，Vol.16Issue(1)：183-187,5.DOI:10.3969/j.issn.1673-8225.2012.01.040
从母系遗传研究肾阴虚型慢性再生障碍性贫血的发病机制
Pathogenesis of chronic aplastic anemia suffering from kidney yin deficiency through the maternal genetics
摘要
Abstract
BACKGROUND: Several laboratories have reported unexpectedly large number of mitochondrial mutations in leukemia. But the direct relations hip between mitochondrial mutations and chronic a plastic anemia (CAA) has not studied yet. OBJECTIVE: To study the mitochondrial mutations of CAAsuffered from kidneyyin deficiency and kidney yang deficiency.andCAA suffered from kidney yin deficiency in order to further study the pathogenesis of CAA.METHODS: The bone marrow and the oral epithelium were obtained from 10 patients with CAA suffered from kidney yindeficiency and 5 patients with CAA suffered from kidney yang deficiency. DNA was extracted and underwent the entireRESULT SAND CONCLUSION: The entire sequencing of mitochondrial DNA in CAA suffer from kidney yin deficiency showed that the mutations were occurrence in the areas that closely related with mitochondrial oxidative respiratory chain, it included themutations in CAA suffered from kidney yang deficiency were not obvious. We are led to conclude that mitochondrial gene mutation can change the expression of respiratory chain enzyme complex in CAA patients, which results in energy metabolismimpairment may participate in the physiological and athology processes of hem atopoietic failure,Functional impairment of mitochondrial respiration chain induced by gene mutation may be an important reason of hematopoietic failure in CAA.And this change is closely related to maternal inheritance and kidney yin deficiency.关键词
慢性再生障碍性贫血/肾主骨生髓/线粒体/母系遗传/突变分类
医药卫生引用本文复制引用
崔兴,张文静,蔡治国,徐瑞荣,刘菲,王敬毅,刘奎..从母系遗传研究肾阴虚型慢性再生障碍性贫血的发病机制[J].中国组织工程研究,2012,16(1):183-187,5.基金项目
本项研究由国家十一五科技攻关计划(2007BAI20B06)项目和"泰山学者"建设工程专项经费资助. （2007BAI20B06）
