中国组织工程研究2012，Vol.16Issue(2)：211-214,4.DOI:10.3969/j.issn.1673-8225.2012.02.004
大鼠腭中缝牵张成骨中骨形态发生蛋白7的作用
Role of bone morphogenetic protein-7 in the distraction osteogenesis of rat mid-palatal suture
摘要
Abstract
BACKGROUND: Experiments have confirmed that bone morphogenetic protein-7 can induce bone and cartilage formation; it can also promote bone formation in the process of distraction osteogenesis. OBJECTIVE: To explore the role of bone morphogenetic protein-7 in the suture distraction osteogenesis of rat mid-palatal suture and to detect the changes of bone morphogenetic protein-7 under the mechanical expansion force. METHODS: Expansionary force was applied on rats using a self-made expansing arch spring for binoculus to construct maxillary expansion rat model. Rat mid-palatal sutures were randomly collected on 1, 3, 5, 7, 9, 12 and 14 days after model construction; real-time PCR was performed to detect the changing regularities of the target genes. RESULTS AND CONCLUSION: The expression of the bone morphogenetic protein-7 mRNA in the rat mid-palatal sutures increased gradually on 3, 9, 12 and 14 days after model construction (P < 0.05). These findings demonstrate that bone morphogenetic protein-7 mRNA expression is significantly increased in the distraction osteogenesis process of rat mid-palatal sutures under the stimulus of mechanical force.关键词
骨形态发生蛋白7/牵张成骨/大鼠/腭中缝/骨组织构建分类
医药卫生引用本文复制引用
李威,李鹍,王培军,韩晶莹..大鼠腭中缝牵张成骨中骨形态发生蛋白7的作用[J].中国组织工程研究,2012,16(2):211-214,4.基金项目
黑龙江省自然科学基金(D20965) （D20965）
市科委青年科技创新人才基金资助项目(2010RFQXS113). （2010RFQXS113）
