中国组织工程研究2012，Vol.16Issue(3)：401-404,4.DOI:10.3969/j.issn.1673-8225.2012.03.004
电纺纳米纤维可降解输尿管支架肌肉埋植的降解性能
Degradation of biodegradable ureteral stent composed of electrospun nanofibers implanted into the muscle
摘要
Abstract
BACKGROUND: The author has completed the preliminary investigation on degradation of electrospun nanofiber poly lactic acid- glycolic acid copolymer (PLGA) biodegradable ureteral stent material in vitro and found the degradation time of 80/20 PLGA material in urine could meet the clinical needs. OBJECTIVE: To investigate the degradation properties of 80/20 PLGA electrospun nanofiber ureteral stents implanted in muscle. METHODS: The 80/20 PLGA electrospun nanofiber ureteral stents were prepared by electrostatic spinning. The degradation properties of the stents in rabbit paravertebral muscle were observed. RESULTS AND CONCLUSION: Electrospun nanofiber ureteral stents were successfully prepared with a good morphology under scanning electron microscopy. At 10 weeks of degradation of 80/20 PLGA electrospun nanofiber ureteral stents, their mass was 60% of initial mass, and fracture and disintegration of the stents could be seen. Degradation rate of the stents was slightly decreased than that in vitro, but they were still able to meet the clinical needs of biodegradable ureteral stents.关键词
电纺丝/聚乳酸-羟基乙酸共聚物/肌肉埋植/降解性能/生物材料/可降解输尿管分类
医药卫生引用本文复制引用
张龙,王晓庆,姜凤鸣,管旌旌,王春喜..电纺纳米纤维可降解输尿管支架肌肉埋植的降解性能[J].中国组织工程研究,2012,16(3):401-404,4.基金项目
国家自然科学基金项目项目(50973043),项目名称:新型梯度降解高分子材料输尿管支架的研制. （50973043）
