中国组织工程研究2012，Vol.16Issue(3)：522-526,5.DOI:10.3969/j.issn.1673-8225.2012.03.032
软骨组织工程中支架材料的文献回顾
Literature review of scaffold materials in cartilage tissue engineering
摘要
Abstract
BACKGROUND: Four types scaffold materials in cartilage tissue engineering have been reported at present, they are natural polymers, synthetic biodegradable materials, new composite biomaterials of natural materials and natural polymers, and nano-materials. OBJECTIVE: To summarize the literatures at home and abroad in recent years about scaffold materials in tissue engineering and to explore the problems and application prospects currently. METHODS: A computer-based online search of literatures related to scaffold materials in cartilage tissue engineering from January 1997 to January 2011 was performed in PubMed database and CNKI database using the key words of "natural polymer materials, synthetic materials, new biological materials, nanometer materials, scaffold materials, cartilage tissue engineering" in English and in Chinese. A total of 33 literatures excluded repetitive studies were chosen to summarize. RESULTS AND CONCLUSION: Single materials of tissue engineering are gradually replaced by composite materials which have higher pore porosity, lower antigenicity, better histocompatibility, and better abilities for adhesion and proliferation of chondrocytes. Biodegradable materials can be processed with exact shapes by computer-aided design and three-dimensional printing rapid prototyping technology. The future direction of development is to develop a type of biodegradable material which has an exact shape, a certain mechanical strength and appropriate aperture based on inner support scaffolds with slow rate of degradation.关键词
天然高分子材料/人工合成材料/新型生物材料/纳米材料/支架材料/软骨组织工程分类
医药卫生引用本文复制引用
吴军成,霍然,吕仁荣..软骨组织工程中支架材料的文献回顾[J].中国组织工程研究,2012,16(3):522-526,5.基金项目
山东省中青年科学家奖励基金计划项目(2004BS02009). （2004BS02009）
