中国组织工程研究2012，Vol.16Issue(4)：709-712,4.DOI:10.3969/j.issn.1673-8225.2012.01.032
骨延长患者诱导型一氧化氮合酶的表达
Expression of inducible nitric oxide synthase in bone lengthening patients
胡新永 1陈建文 1王义生2
作者信息
- 1. 国家康复辅具研究中心附属康复医院矫形骨科,北京市,100176
- 2. 郑州大学第一附属医院骨科,河南省郑州市,450052
- 折叠
摘要
Abstract
BACKGROUND: It is unknown that how to transfer the impetus of distraction into the message of bone regeneration in limb lengthening.OBJECTIVE: To study the dynamic expression of inducible nitric oxide synthase (iNOS) in bone lengthening patients.METHODS: Totally eight patients whose tibia and fibula are shorten in single lower limb were involved in bone lengthening group.The serum iNOS levels of the patients were measured respectively at 3 days preoperatively, at 3, 7, 8, 11, 13 days postoperatively, stopping bone lengthening, at 3, 15, 30 days after stopping bone lengthening, removing the external lengthening apparatus and at 30 days after removing the external lengthening apparatus. Eight patients with similar age to the bone lengthening group were selected as control.RESULTS AND CONCLUSION: The serum iNOS levels in the bone lengthening group began to increase at first day after the distraction (the eighth day after operation) and the peak values was at the stopping bone lengthening. The expression of iNOS in the bone lengthening group was significantly higher than that of the control group at every time point from the first day after the distraction to the day of stopping bone lengthening (P < 0.01). The serum iNOS levels in the bone lengthening group at 3 days after stopping the bone lengthening was also higher as compared with the control group (P < 0.05). It is indicated that the higher expression of iNOS is one of the molecular biological mechanisms of bone lengthening.关键词
骨延长/诱导型一氧化氮合酶/Ilizarov外固定延长器/胫腓骨/牵张分类
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胡新永,陈建文,王义生..骨延长患者诱导型一氧化氮合酶的表达[J].中国组织工程研究,2012,16(4):709-712,4.
