中国组织工程研究2012，Vol.16Issue(6)：1111-1114,4.DOI:10.3969/j.issn.1673-8225.2012.06.035
骨髓间充质干细胞向神经细胞分化的相关信号通路研究现状
Current researches of signal pathways involved in bone marrow mesenchymal stem cells differentiation into nerve cells
摘要
Abstract
BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) can be induced to differentiate into nerve cells in appropriate culture conditions.OBJECTIVE: To review various signal pathways referred to the process of BMSCs differentiation into nerve cells.METHODS: The databases of CNKI and Web of Science were searched for the articles about BMSCs differentiation into nerve cells published from January 2001 to December 2010. The key words were "bone marrow mesenchymal stem cells, neural cells, signal" in Chinese and English. Finally, 19 articles were included in result analysis.RESULTS AND CONCLUSION: The relationship between cell signaling pathways is complex, and thus it is more accurate for the regulation of cell-specific responses. A series of signal transduction pathways involved in the regulation of bone marrow mesenchymal stem cells differentiate into nerve cells, including Ca2+ signaling pathway, protein kinase A signaling pathway, MEK-ERK pathway, PI3K/Akt signaling pathway, MAPK signaling pathway, which are interrelated with each other.关键词
信号通路/骨髓间充质干细胞/神经细胞/分化/综述文献分类
医药卫生引用本文复制引用
刘振东,王静成,杨建东..骨髓间充质干细胞向神经细胞分化的相关信号通路研究现状[J].中国组织工程研究,2012,16(6):1111-1114,4.基金项目
国家自然科学基金资助项目(81071466). （81071466）
