中国组织工程研究2012，Vol.16Issue(6)：1137-1140,4.DOI:10.3969/j.issn.1673-8225.2012.06.041
自体骨髓单个核细胞移植治疗糖尿病下肢周围神经病变
Autologous bone marrow mononuclear cells transplantation for the treatment of diabetic peripheral neuropathy of lower limb
张会峰 1赵志刚 1袁慧娟 1虎子颖 1马跃华1
作者信息
- 1. 河南省人民医院二内内分泌科,河南省郑州市,450003
- 折叠
摘要
Abstract
BACKGROUND: Studies have shown that autologous bone marrow mononuclear cells transplantation can treat the diabetic peripheral neuropathy (DPN) of lower limb. It can improve the clinical symptom by promoting the angiogenesis and increasing vascular endothelial growth factor and neurotrophic factor.OBJECTIVE: To evaluate the clinical efficacy of autologous bone marrow mononuclear cells transplantation for the treatment of DPN of lower limb.METHODS: 60 lower limbs of 30 patients with DPN were divided into two groups by treatment method, 30 lower limbs received autologous stem cells transplantation (treatment group), 30 lower limbs did not receive autologous stem cells transplantation as control group (control group).RESULTS AND CONCLUSION: At 4 weeks after transplantations, the total efficiency rate in treatment group was higher than that in control group (P < 0.05). After treatment, the TSS in two groups was significantly decreased, and the TSS in treatment group was lower than that in the control group (P < 0.01). The sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) of tibial nerve and common peroneal nerve in treatment group were faster than that in the control group (P < 0.01), no related complication or adverse effects were observed in all patients. Autologous bone marrow stem cells transplantation has a good clinical efficacy on the treatment of lower limb DPN.关键词
骨髓单个核细胞/糖尿病周围神经病变/自体移植/下肢/干细胞移植分类
医药卫生引用本文复制引用
张会峰,赵志刚,袁慧娟,虎子颖,马跃华..自体骨髓单个核细胞移植治疗糖尿病下肢周围神经病变[J].中国组织工程研究,2012,16(6):1137-1140,4.
