中国组织工程研究2012，Vol.16Issue(7)：1165-1168,4.DOI:10.3969/j.issn.1673-8225.2012.07.007
基质金属蛋白酶7和转化生长因子β1在病理性瘢痕中的表达:与正常瘢痕及正常皮肤组织比较
Expressions of matrix metalloproteinase 7 and transforming growth factor beta-1 in pathological scars compared with normal scars and healthy skin tissues
刘爱东 1王玥 1庞久玲 2李德艳 1刘军2
作者信息
- 1. 唐山职业技术学院医学校区,河北省唐山市,063000
- 2. 唐山市工人医院烧伤整形科,河北省唐山市,063000
- 折叠
摘要
Abstract
BACKGROUND: A thorough study on pathological scar pathogenesis at gene and protein level is of great value.OBJECTIVE: To explore the expressions of matrix metalloproteinase 7 and transforming growth factor β1.METHODS: Pathological scar samples were collected after surgeries carried out in the Department of Burn and Plastic Surgery,Workers' Hospital of Tangshan, between 2004 and 2009. There were 54 samples of keloid and 42 samples of hypertrophic scar.A total of 45 regular scar samples gained from surgical resection due to noninfectious diseases were selected as control group.The expressions of matrix metalloproteinase 7 and transforming growth factor β1 were semi-quantitatively examined by flowcytometry.RESULTS AND CONCLUSION: The expression of matrix metalloproteinase 7 and transforming growth factor β1 in pathologicalscars were significantly higher than that in the normal scars and healthy skin tissues. The expressions of matrix metalloproteinase7 and transforming growth factor β1 in normal scars were significantly higher than those in the healthy skin tissues. Theexpressions of matrix metalloproteinase 7 in pathological scars and normal scars were positively correlated with the expression oftransforming growth factor β1. These results indicate that the high level expression and synergistic effect of matrixmetalloproteinase 7 and transforming growth factor β1 may promote the occurrence and development of pathological scars.关键词
病理性瘢痕/基质金属蛋白酶7/转化生长因子β1/协同作用/流式细胞术分类
医药卫生引用本文复制引用
刘爱东,王玥,庞久玲,李德艳,刘军..基质金属蛋白酶7和转化生长因子β1在病理性瘢痕中的表达:与正常瘢痕及正常皮肤组织比较[J].中国组织工程研究,2012,16(7):1165-1168,4.
