中国组织工程研究2012，Vol.16Issue(8)：1387-1390,4.DOI:10.3969/j.issn.1673-8225.2012.08.013
大节段生物活性陶瓷多孔支架肌内血管化:3年期3D-数字减影血管造影观察
Three-dimensional digital subtraction angiography observation of vascularization of large-segment bioactive ceramic scaffolds implanted into skeletal muscle within 3 years
摘要
Abstract
BACKGROUND: The core of the artificial bone material activating, biological bonding with autologous bone and completion of autologous bone creeping substitution in vivo is vascularization. The occurrence of vascularization is still unclear. OBJECTIVE: To observe the vascularization of the large segment of bioactive ceramic scaffold implanted into the skeletal muscle for 3 years.METHODS: Ten male dogs were selected for implanting porous hydroxyapatite-polylactic acid scaffold (diameter of 1.5 cm, length of 4-4.5 cm) in skeletal muscles. Thirty-six months later, three-dimensional digital subtraction angiography (3D-DSA) was performed.RESULTS AND CONCLUSION: All the dogs underwent operation and 3D-DSA successful and the results were similar. 3D-DSA showed: nutrient arteries derived from the femoral artery and deep femoral artery and pointed to the hydroxyapatite-polylactic acid scaffold, the branches inserted into the hydroxyapatite-polylactic acid scaffold. 3D-DSA is an effective means of observation of vascularization of artificial bone in vivo. The integral arterial and venous blood circulatory system can be established in hydroxyapatite-polylactic acid scaffold implanted in skeletal muscle for 3 years.关键词
生物活性陶瓷/血管化/数字减影血管造影技术/羟基磷灰石/聚乳酸/支架分类
医药卫生引用本文复制引用
任翔,黄鹏,姚一民,冯怀志,张文华,翁杰,李硕,张聪..大节段生物活性陶瓷多孔支架肌内血管化:3年期3D-数字减影血管造影观察[J].中国组织工程研究,2012,16(8):1387-1390,4.基金项目
全军" 十一五" 科技攻关课题项目(06G049). （06G049）
