中国组织工程研究2012，Vol.16Issue(8)：1463-1466,4.DOI:10.3969/j.issn.1673-8225.2012.08.030
脂质体在基因治疗中的应用研究及进展
Research and application of liposomes in gene therapy
摘要
Abstract
BACKGROUND: Liposome is a safe and frequently-used genonic vector. But the composition and structure of liposome limit itsapplication and development. Transfection efficiency and treatment effect of the liposome become the most important referencefactors in the research of gene therapy.OBJECTIVE: To review the application and research progress of liposome in gene therapy.METHODS: CNKI database, CALIS database and KANGJIAN database were searched for articles from 1995 to 2011 with the keywords of “liposome, gene, transfection" in Chinese and English.RESULTS AND CONCLUSION: Liposome as the genonic vector has many advantages in higher security, lower immunogenicity,less toxicity and easy preparation as compared with viral vector. Therefore, it has been successfully applied in many animalexperiments in vivo and in vitro. The application of liposome is restricted by lower transfection efficiency and target activity. So thehot spot of study in gene therapy involves in liposome is to improve the transfection efficiency. The better therapeutic effect isobtained by reaching the treatment concentration in target cells or organ.关键词
脂质体/基因/转染/靶细胞/靶器官/治疗浓度分类
医药卫生引用本文复制引用
江献芳,周诺..脂质体在基因治疗中的应用研究及进展[J].中国组织工程研究,2012,16(8):1463-1466,4.基金项目
国家自然科学基金资助项目(30760273、30960421) （30760273、30960421）
广西壮族自治区自然科学基金资助项目(桂科自0991013Z). （桂科自0991013Z）
