中国组织工程研究2012，Vol.16Issue(12)：2171-2174,4.DOI:10.3969/j.issn.1673-8225.2012.12.019
三种贵金属烤瓷合金与高糖对小鼠成纤维细胞L-929增殖的影响
Effects of three kinds of noble ceramic alloys and high glucose on proliferation of L-929 cells in mice
谢晖 1范兆乾 2方颖1
作者信息
- 1. 广州医学院口腔医院,广东省广州市,510140
- 2. 河南煤化集团安化分公司设备制作部,河南省安阳市,455133
- 折叠
摘要
Abstract
BACKGROUND: The oral environments of diabetic patients were special, and there are few studies on safety of dental restorative materials for these patients. OBJECTIVE: To observe the effects of three kinds of noble ceramic alloys and high glucose on proliferation of mouse fibroblasts L-929 cultured in vitro. METHODS: 89% Au-base alloy, 74% Au-base alloy and silver-palladium alloy were immersed in mediums with different glucose concentrations (11.1, 22.2, and 33.3 mmol/L) for extraction. Mouse fibroblasts L-929 were co-cultured with the extraction. The control group was set up. RESULTS AND CONCLUSION: Proliferative activities of L-929 cells cultured in mediums with different glucose concentrations and different noble ceramic alloys were different, and the two-factor interactions at 24 and 72 hours existed (P < 0.05). The proliferation of L-929 cells cultured by 89% Au-base alloy and 22.2 mmol/L high glucose concentration was more faster than the control group (P=0.004), while the silver-palladium alloy could inhibit the proliferation (P < 0.001). However, no significant difference was found among the 74% Au-base alloy groups with different glucose concentrations and the control group. It is suggested that 74%Au-alloy with different glucose concentrations among these three kinds of materials has the least effects on cell proliferation.关键词
贵金属烤瓷合金/高糖/金合金/银钯合金/小鼠成纤维细胞/增殖分类
医药卫生引用本文复制引用
谢晖,范兆乾,方颖..三种贵金属烤瓷合金与高糖对小鼠成纤维细胞L-929增殖的影响[J].中国组织工程研究,2012,16(12):2171-2174,4.
