中国组织工程研究2012，Vol.16Issue(12)：2212-2216,5.DOI:10.3969/j.issn.1673-8225.2012.12.028
吲哚美辛微球的制备及其包封率和释放性能
Preparation, entrapment efficiency, and release property of indomethacin microspheres
摘要
Abstract
BACKGROUND: Indomethacin requires multiple doses to achieve treatment effect because of its short half-life in ocular. OBJECTIVE: To prepare indomethacin microspheres and analyze its entrapment efficiency and release property. METHODS: Indomethacin microspheres were prepared by emulsion solvent evaporation using poly lactic acid-glycolic acid copolymer and polyacrylic acid resin based on their good safety. The influences of preparation parameters on encapsulation efficiency and release property were investigated, such as different organic solvent (dichlormethane, acetone), different proportions of polymer, different pH values and osmotic pressures. RESULTS AND CONCLUSION: The microspheres were spherical shape with a smooth and imperforation surface, and had fine dispersibility at a diameter of 2-3 μm. The dichloromethane, lower weight of polyacrylic acid resin, lower pH and osmotic pressure in water medium could result in higher entrapment efficiency. The entrapment efficiency was the highest and the release rate was the slowest at 1:3 of poly lactic acid-glycolic acid copolymer and polyacrylic acid resin.关键词
吲哚美辛/聚乳酸-羟基乙酸共聚物/聚丙烯酸树脂类/微球/乳化溶剂挥发法分类
医药卫生引用本文复制引用
高颖,吴艺君,南开辉,李文生,温俊..吲哚美辛微球的制备及其包封率和释放性能[J].中国组织工程研究,2012,16(12):2212-2216,5.基金项目
浙江省大学生科技创新活动计划(新苗人才计划)资助项目(2010R413051),课题名称:吲哚美辛眼用缓释微球的制备 （新苗人才计划）
浙江省医药卫生科学研究基金资助项目(2009A138),课题名称:吲哚美辛缓释植入体防治增生性玻璃体视网膜病变的实验研究 （2009A138）
温州市科技局面上项目资助(Y20090014),课题名称: （Y20090014）
