畜牧与兽医2011，Vol.43Issue(12)：10-15,6.
三聚氰胺与三聚氰酸混合物对小鼠肾脏的影响
Effect of melamine and cyanuric acid mixture administration on kidneys in mice
朱金凤 1尤华 1佘锐萍 2常玲玲 1岳卓 1苏丽芳 1毛晶晶1
作者信息
- 1. 中国农业大学动物医学院,北京100193
- 2. 中国动物疫病预防控制中心,北京100125
- 折叠
摘要
Abstract
the mice from three group were administered intragastrically with low dosage (0.6 mg · kg-1) , moderate dosage (3 mg · kg-1 ) and high dosage (15 mg · kg-1) , respectively for 30 days. Simultaneously, the control mice were administered with equivalent corn oil. At 24 h after the last administration, the blood was collected and then all the mice were sacrificed. The serum samples were measured for the contents of Cr and blood urea nitrogen (BUN) and the pathological changes of kidney was examined by light and electron microscopes. The results showed that compared with control mice, the contents of Cr and BUN increased obviously (P<0. 01 or P<0.05) in moderate and high dosage groups. HE and PAS staining results showed that the tubular lumen dilated mildly in low and moderate dosage groups and soluble crystals were found in local kidney of moderate dosage group. Yellow or brown-yellow crystals were observed in kidney tubules of high dosage group. The tubular lumen dilated severely and epithelial cells of the renal tubular turned flat. In addition, the renal brush border membrane was damaged severely and renal interstitial fibrosis was accompanied by lymphocytic infiltrates.关键词
三聚氰胺/三聚氰酸/小鼠/肾脏Key words
melamine/ cyanuric acid/ mice/ kidney分类
农业科技引用本文复制引用
朱金凤,尤华,佘锐萍,常玲玲,岳卓,苏丽芳,毛晶晶..三聚氰胺与三聚氰酸混合物对小鼠肾脏的影响[J].畜牧与兽医,2011,43(12):10-15,6.
