西南国防医药2012，Vol.22Issue(3)：268-271,4.DOI:10.3969/j.issn.1004-0188.2012.03.014
紫杉醇联合奥沙利铂或顺铂治疗晚期非小细胞肺癌疗效观察
Curative effects of paclitaxel combined with oxaliplatin or cisplatin on advanced non-small cell lung cancer
陈方红 1王剑 1黎启菊1
作者信息
- 1. 615000,四川,西昌,四川省凉山州第一人民医院肿瘤科
- 折叠
摘要
Abstract
Objective To make comparison of curative effects and toxic reaction on advanced non - small cell lung cancer ( NSCLC)between the treatment by paclitaxel( PTX)combined with oxaliplatin and that by PTX combined with cisplatin. Methods Fifty two patients with advanced NSCLC and receiving initial treatment( in III B/IV stage, with ECOG score of 0 - 2 points and with fine organ function and hematopoietic function)were randomly divided into two groups. In the paclitaxel - cisplatin group( 25 cases,TP group ),each patient received 135 mg/m2 paclitaxel in d 1 and 25 mg/m2 cisplatin from d 1 to d 3. In the paclitaxel - oxaliplatin group ( 27 cases, TO group ), each one received the same dosage of paclitaxel as the TP group and 125 mg/m2 oxaliplatin in d 1. Both groups were treated by intravenous drip with each 21 d as a period. Every patient received at least 2 periods. After two periods of chemotherapy,the curative effects and toxic reaction were assessed. Results The effective rate of TO and TP group was 37. 0 % and 40. 0% , respectively(P > 0. 05 ). The incidence of aleucocytosis in III to IV degree was 11.1% and 36. 0 % , respectively(P < 0. 05 ). The incidence of gastrointestinal reaction in III to IV degree was 14. 8% and 44. 0% , respectively( P < 0. 05 ). The incidence of neurotoxicity in I + II degree was 59. 2% and 20. 0% , respectively( P <0. 05 ). Conclusion Paclitaxel combined with oxaliplatin or cisplatin are effective in the treatment of advanced NSCLC. The short term curative effects of both methods are similar, but the hematological toxicity and adverse reaction in alimentary tract caused by the combination of paclitaxel and oxaliplatin are less than those caused by the combination of paclitaxel and cisplatin.关键词
非小细胞肺癌/奥沙利铂/紫杉醇/顺铂Key words
non-small cell lung cancer/oxaliplatin/paclitaxel/cisplatin分类
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陈方红,王剑,黎启菊..紫杉醇联合奥沙利铂或顺铂治疗晚期非小细胞肺癌疗效观察[J].西南国防医药,2012,22(3):268-271,4.
