新医学2011，Vol.42Issue(11)：726-729,4.DOI:10.3969/g.issn.0253-9802.2011.11.010
精神分裂症患者代谢异常的病例对照研究
Metabolic abnormality in patients with drug-naive schizophrenia: Case-control study
摘要
Abstract
Objective: To investigate the metabolic abnormality in patients with drug-naive schizophrenia andpossible metabolic effect derived from ziprasidone. Methods: Oral ziprasidone treatment was carried out on 29 cases of drug-naive schizophrenia admitted patients 4 weeks under natural observational situation. The height, weight, waistline, hipline, total cholesterol, triglyceride, HDL, LDL, apolipoprotein A-l (aPOAl), apolipopro-tein BlOO(aPOB100) , fasting blood-glucose, fasting insulin and C-peptide were recorded before and after treatment. Meanwhile, insulin resistance( IR) , waist-hip ratio( WHR)and BMI were calculated. Forty-four healthy volunteers were enrolled as controls. Results; Significant increase of WHR, fasting insulin, C-peptide and IR were revealed in drug-naive schizophrenia patients, when comparing with those in control(P <0. 05). However, significant reduction of HDL and aPOAl were revealed in drug-naive schizophrenia patients ( P < 0. 05 ). Furthermore, significant alleviation of fasting blood-glucose was observed in drug-naive schizophrenia patients after therapy(P< 0. 05). Conclusion; Glucose and lipid metabolic abnormality may complicate with schizophrenia Thus ziprasidone , which mildly affects the glucose and lipid metabolism, should be considered in long-term treatment of schizophrenia关键词
齐拉西酮/首次治疗/精神分裂症/病例对照/代谢异常Key words
Ziprasidone/ Drug-naive/ Schizophrenia/ Case-control/ Metabolic abnormality引用本文复制引用
吴小立,文飞,钟智勇,陶炯..精神分裂症患者代谢异常的病例对照研究[J].新医学,2011,42(11):726-729,4.基金项目
广东省科技计划项目(2009B080701080) （2009B080701080）
