新医学2011，Vol.42Issue(12)：778-781,4.DOI:10.3969/g.issn.0253-9802.2011.12.005
乙型肝炎病毒母婴垂直传播相关临床因素分析
Clinical analysis of HBV vertical transmission
摘要
Abstract
Objective; To discover the clinical factors influencing HBV vertical transmission through analyzing the clinical data of gravida with HBV infection. Methods; Seven hundred and eleven pregnant women with HBV infection, who gave birth in obstetric department of the third affiliated hospital of SUN Yat-sen University were involved. Their clinical data such as HBV DNA level, obstetric situation, lactation situation and whether their babies acquired HBV infection were retrospectively analyzed and compared between HBeAg-positive gravida and HBeAg-negative gravida. Results; No statistical differences were found in age, gestational week, gravidity, parity, threatened abortion, threatened premature delivery, premature rupture of membrane, modes of delivery, spouse HBsAg positive rate, newborn weight and gender between the two groups. However, significant differences existed in HBV DNA level, abnormal liver function during pregnancy, intramuscular administration of HBIG during pregnancy, newborn HBsAg positive and (or) HBV DNA positive rate and the number of babies acquiring HBV infection between the two groups. The rate of HBV vertical transmission was 0. 84%. When maternal HBV DNA level was no less than 10" copies/L, the relative risk of vertical transmission was 20. Conclusion; HBeAg-negative gravida had no vertical transmission. The higher HBV DNA level is, the grater the risk of vertical transmission is.关键词
乙型肝炎病毒/乙型肝炎病毒e抗原/乙型肝炎病毒脱氧核糖核酸/母婴传播Key words
Hepatitis B virus/ Hepatitis B e antigen/ Hepatitis B virus deoxyribonucleic acid/ Vertical transmission引用本文复制引用
谌小卫,潘文涛,杨越波,尹玉竹,李小毛..乙型肝炎病毒母婴垂直传播相关临床因素分析[J].新医学,2011,42(12):778-781,4.基金项目
广东省科技厅基金计划项目(2007 B030502012,2008 B060600023),广东省科技计划项目(2005 B340201006),广东省中医药局科技基金资助项目(1060166) （2007 B030502012,2008 B060600023）
