摘要
Abstract
Objective: To elucidate the relationship among pro-inflammatory cytokine (IL-1, IL-6, TNF-a), anti-inflammatory cytokine (IL-10) and MMP-2 and their effects on the stability of plaque in unstable angina. Methods-. The concentrations of IL-1, IL-6, TNF-a, IL-10, MMP-2 and TIMP-2 were analyzed using ELISA in 170 patients and 30 healthy control subjects. Patients were divided into two groups, stable angina (n = 35) and unstable angina (n = 135). Results; The serum levels of IL-1, IL-6, TNF-a, IL-10, MMP-2 and TIMP-2 were significantly higher in UAP group and SAP group compared with the healthy control group ( P < 0. 05 ) , and so were the ratio of MMP-2/TIMP-2 and( IL-1 + IL-6 + TNF-a)/IL-10 (P < 0. 05). The levels of above mentioned cyto-kines and ratios in patients with unstable angina were significantly higher than those with stable angina (P < 0. 05). Correlation analysis revealed the level of MMP-2 was positively related to the levels of IL-1, IL-6, IL-10 and TNF-a. In multiple linear regression analysis, significant positive correlations were found between MMP-2 and IL-10, (IL-1 +IL-6 + TNF-a) /IL-10 and fasting blood glucose separately in patients with unstable angina. Conclusion; The imbalance of proinflammation/anti-inflammation could lead to unstability of the plaque through the regulation of MMP-2, which could trigger unstable angina.关键词
心绞痛/不稳定型/细胞因子/基质金属蛋白酶-2Key words
Angina, unstable/ Cytokines/ Matrix metalloproteinase-2
