新医学2011，Vol.42Issue(12)：805-807,3.DOI:10.3969/g.issn.0253-9802.2011.12.013
重组人促红素联合米多君对终末期心力衰竭患者心功能及血流动力学的影响
Effect of association of erythropoietin and midodrine on the cardiac function and hemodynamics in patients with end-stage heart failure
摘要
Abstract
Objective; To investigate the effect of association of Erythropoietin and Midodrine on the cardiac function and hemodynamics in patients with end-stage heart failure. Methods; Forty-three patients with end-stage heart failure were recruited into this study. Patients were randomly divided into two groups, combination treatment group (n =22) and control group (n =21). All patients in the two groups were treated with a standard anti-heart failure therapy and only patients in combination treatment group were administrated erythropoietin, iron and Midodrine. All subjects were followed up for 3 months. The levels of blood pressure, hemoglobin, BNP, LVEF and mean pulmonary artery pressure ( mPAP) were examined at the beginning and the end of the study. The rates of cardiovascular events in the two groups were recorded. Results: The levels of blood pressure and hemoglobin were significantly increased and the levels of BNP and the rates of rehospitalization was significantly decreased in the combination treatment group ( P < 0. 05). There was no significant difference in LVEF and mPAP between the two groups. Conclusion; On the basis of standard therapy, combination of erythropoietin and midodrine treatment may improve the cardiac function and hemodynamics in patients with end-stage heart failure.关键词
心力衰竭/重组人促红素/米多君/心功能/血流动力学Key words
Heart failure/ Erythropoietin/ Midodrine/ Cardiac function/ Hemodynamics引用本文复制引用
吴钰燕,程颖,解强,林桂雄,冯燕玲,李劲草,卓裕丰,张鹏,黄冰生..重组人促红素联合米多君对终末期心力衰竭患者心功能及血流动力学的影响[J].新医学,2011,42(12):805-807,3.基金项目
广州市番禺区科技局科技计划项目(2011-Z-03-39) （2011-Z-03-39）
