疑难病杂志2012，Vol.11Issue(3)：164-167,4.DOI:10.3969/j.issn.1671-6450.2012.03.003
最佳LDL-C目标水平对症状性颈动脉狭窄患者发生终点事件的长期随访及超声评价
The long term follow up and evaluation by ultrasound in research of the best target lipid levels in patients with symptomatic carotid artery stenosis
摘要
Abstract
Objective To stduy the effect, security and ultrasound evaluation of the best target lipid levels for the prevention of cerebral infarction and recurrence in symptomatic carotid artery stenosis patients. Methods A total of 337 incipient patients who suffered from symptomatic carotid artery stenosis were randomly divided into treatment group ( 236 cases ) and contral group ( 101 cases ). The treatment group modulated the level of LDL-C in range of 1. 82 ～ 2. 10 mmol/L. The control group modulated the level of LDL-C less than 1. 82 mmol/L. The functional health, endpoint event and ultrasonic indexes after three years, five years treatment were compared between the two groups. Results The treatment group had higher functional health than that in the control group after 3 and 5 years follow up( P <0. 01 ). In the treatment group, the occurrence and recurrence of cerebral infarction, cardiac events were significantly lower than those in the control group ( P < 0.05 ). The 5 years mortality rate in the treatment group were lower than that in the control group( P < 0. 05 ). The plaque was more steady than that of control group through the ultrasound re-examination after 3 and 5 years follow up( P < 0.05 ). The carotid IMT and plaque index in treatment group were lower than those in the control group( P < 0. 01 ). It showed statistical diffe rence between two groups in the indexes of PSV, SR, PI, EDV and RI( P <0.05, P <0.01 ). Conclusion For the patients with symptomatic carotid artery stenosis, modulating the lipid level in the range of 1. 82 ～2. 10 mmol/L could effectively reduce the incidence of cerebral infarction and recurrence. Furthermore, the carotid ultrasound was a convenient and reliable method to evaluate the therapeutic effect.关键词
颈动脉狭窄/调脂治疗/终点事件/预防/超声检查/长期随访Key words
Carotid arterial stenosis/ Lipid modulating therapy/ Endpoint event/ Prevention/ Ultrasonography/ Long term follow up引用本文复制引用
王连芹,彭红兵,王玉,魏玉清,李国锋,李俊青,宁海春..最佳LDL-C目标水平对症状性颈动脉狭窄患者发生终点事件的长期随访及超声评价[J].疑难病杂志,2012,11(3):164-167,4.基金项目
河北省2010年科学技术研究与发展计划项目(No.10276105D-30) （No.10276105D-30）
