疑难病杂志2012，Vol.11Issue(4)：241-244,4.DOI:10.3969/j.issn.1671-6450.2012.04.001
伊布利特和胺碘酮治疗心房颤动和心房扑动的Meta分析
A Meta analysis of effect of ibutilide and amiodarone on atrial fibrillation and atrial flutter
程琳 1夏豪 1胡丽丽1
作者信息
- 1. 430060,武汉大学人民医院心血管内科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of ibutilide and amiodarone for treatment of atrial fibrillation ( AF ) and atrial flutter ( AFL ). Methods Randomized controlled trials ( RCT ) included written in Chinese and English concerning butilide and amiodarone in treatment of atrial fibrillation and atrial flutter were collected from 2007 to 2011 in a Meta analysis. The RevMan 5. 1 software of Cochrane Coordination Net was used for statistical analysis. Results There were nine papers reached the criteria enrolled in the study. ( 1 )Cardio-version rate of using ibutilide for treating AF ( 76. 60% ) was higher than that of amiodarone ( 57. 83% )( OR =2.38, 95% CI 1. 57 ~3. 59, P <0. 01 ). No bias was prompted on the funnel plot. ( 2 )Cardio-version rate of using ibutilide for treating AFL ( 80.00% ) was higher than that of amiodarone ( 28. 17% ) ( OR = 10. 18, 95% CI 4. 72 ~ 21. 96, P < 0. 01 ). ( 3 ) Total cardio-version rate of using ibutilide for treating AF/AFL (81.36% )was higher than that of amiodarone( 60. 91% )(OR = 2.82, 95% CI 1. 54 ~ 5. 15, P < 0. 01 ). ( 4 )The time for cardio-version of using ibutilide for treating AF/AFL was shorter than that of amiodarone( P <0. 01 ),the funnel plot suggested that publication bias might exist. ( 5 )An adverse reaction rate of ibutilide for treating AF/AFL was 20. 18% and amiodarone was 19. 29%( OR =0. 82, 95% CI 0. 37 ~ 1. 80, P =0. 62 ). No significant differences existed between the two medicines. The funnel plot suggested that publication bias might exist. Conclusion Compared with amiodarone, ibutilide is more effective for the treatment of atrial fibrillation and/or atrial flutter, but the safety of both medicines shows no significant difference.关键词
伊布利特/胺碘酮/心房颤动/心房扑动/Meta分析Key words
Ibutilide/ Amiodarone/ Atrial fibrillation/ Atrial flutter/ Meta analysis引用本文复制引用
程琳,夏豪,胡丽丽..伊布利特和胺碘酮治疗心房颤动和心房扑动的Meta分析[J].疑难病杂志,2012,11(4):241-244,4.
