摘要
Abstract
Objective To investigate the expression and correlation between Maspin, VEGF-C and the tumor genesis of the ovary, clinical-pathological variables. Methods Using immunohistochemistry, Maspin and VEGF-C expression of 60 ovarian carcinoma tissues ( 33 serous papillary carcinomas, 7 endometrioid carcinomas, and 20 ovarian mucinous carcinomas ) and 18 benign ovarian tumors, 14 borderline ovarian tumors and 10 normal ovarian tissues were examined and compared. Results The positive expression rates of Maspin and VEGF-C were 65. 0% and 68. 3% respectively, there were significant difference between these expression in tissues of ovarian carcinoma and borderline carcinoma, benign tumor, normal ovarian tissues; over expression of Maspin was not correlated with pathological type and the degree of differentiation( r =0. 125 , P = 0.34; r = -0.037, P =0.778 ), but it was correlated with International Federation of Gynecology and Obstetrics ( FIGO ) stage, presence of metastatic lymph nodes, and the presence of ascites( r = -0. 364, P =0. 004; r =0. 311, P =0. 015; t = - 0. 292, P = 0. 024 ). Over expression of VEGF-C was correlated with presence of metastatic lymph nodes, FIGO stage, and the presence of ascites ( r = - 0. 280, P = 0. 031; r = 0. 377, P = 0. 003 ; r = 0. 384, P = 0. 002 ). Maspin was negatively correlated with VEGF-C( r = - 0. 349, P =0. 006 ). Conclusion Over expression of Maspin and VEGF-C was detected in ovarian carcinoma. High expression of Maspin and VEGF-C are seemed to play a role in ovarian cancer angiogenesis, progression and lymph node metastases. Combination detection the expressions of Maspin and VEGF-C is helpful for evaluating the biological characteristics and predicting the prognosis of ovarian carcinoma.关键词
卵巢癌/Maspin/VEGF-C/免疫组化Key words
Ovarian tumor/ Maspin/ VEGF-C/ Immunohistochemistry
