摘要
Abstract
Objective To evaluate the effects of beta 2 adrenergic agonists on cardiac function in isolated rat hearts. Methods On the basis of Langendorff permission into the isolated rat hearts, cardiac function in the influence of salbuterol sulfate,levalbuterol,metoprolol tartaric acid and formoterol fumarate on systolic pressure( LVSP) ,both the maximum ascending and descending rate ( + dp/dt, - dp/dt max ) of left ventricle, and heart rate ( HR ) were monitored by using medlab recorder system. Results Beta 2 adrenergic agonists significantly increased LVSP,heart rate +dp/dt max and -dp/dt max of all groups compared with the control group (P<0.05). Arrhythmias such as premature systole, tachycardia occurred and developed with the concentration increased. While, effects of levalbuterol and formoterol fumarate were significant weaker than those of salbutamol sulfate (P<0.05). The selective beta 2 adrenergic blockers completely blocked effects of selective beta 2 adrenergic agonists; while selective beta 1 adrenergic partly blockers blocked effects of selective beta 2 adrenergic agonists. Conclusion This study demonstrats that beta 2 adrenergic agonists possess certain degree of toxicity, levalbuterol is safer on heart that albuterol; Formoterol produces less impact on heart than buterol and terbutaline; No significant difference of security occurred between formoterol and levalbuterol.关键词
β2肾上腺素受体激动药/β2肾上腺素受体阻断药/β1肾上腺素受体阻断药/心脏/体外Key words
Beta 2 adrenergic agonists/ Selective beta 2 adrenergic blockers/ Selective beta 1 adrenergic blockers/ Heart, isolated分类
医药卫生
