医药导报2012，Vol.31Issue(2)：159-161,3.DOI:10.3870/yydb.2012.02.008
丙泊酚对脑缺血-再灌注大鼠认知功能障碍与皮质TrkB/Akt通路的影响
Effects of Propofol on Studying and Memory Dysfunction and Cortex TrkB/Akt Pathway in Focal Cerebral Ischemia/reperfusion Injury of Rats
张俊峰 1周武 1王涛2
作者信息
- 1. 湖北省新华医院麻醉科,武汉,430015
- 2. 华中科技大学同济医学院药学院,武汉,430030
- 折叠
摘要
Abstract
Objective To investigate effects and mechanism of propofol on the studying and memory dysfunction after ischemia/reperfusion in rats. Methods Propofol or saline placebo was administered intraperitoneally prior to reperfusion and effects of which on TrkB/Akt pathway in nerve growth factor receptor were studied by Western Blot and immuno-histochemistry in the model of memory and learning dysfunction caused by ischemia/reperfusion (I/R). Results The latent period of I/R group was obviously shorter than that of the control group, ( 121. 98± 15. 56) vs. (210. 78±26. 71 ) s; the number of cumulated stimulation of I/R group was obviously more than that of the control group, (119. 36± 13. 15) vs. (42. 78±5. 22). The severe neuronlogic deficits, studying and memory function induced by ischemia/reperfusion were significantly improved after treated with propofol. TrkB expression and Akt activity were significantly increased by propofol. Conclusion Propofol ameliorates the studying and memory function, which may be associated with TrkB/Akt pathway activation.关键词
丙泊酚/缺血-再灌注/学习/记忆/TrkBKey words
Propofol/ Ischemia/reperfusion/ Studying/ Memory/ TrkB分类
医药卫生引用本文复制引用
张俊峰,周武,王涛..丙泊酚对脑缺血-再灌注大鼠认知功能障碍与皮质TrkB/Akt通路的影响[J].医药导报,2012,31(2):159-161,3.
