医药导报2012，Vol.31Issue(3)：322-325,4.DOI:10.3870/yydb.2012.03.017
舒肝解郁胶囊与西酞普兰治疗老年缺血性脑卒中后抑郁的疗效比较
Efficacy Comparation of Shuganjieyu Capsule and Citalopram on Treatment of Ischemic Poststroke Depression in Aged Patients
苏伟 1那万秋 1李建华 1杨剑虹 1夏青春 1关铁峰1
作者信息
- 1. 浙江省湖州市第三人民医院精神科,313000
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy for treating mild and moderate ischemic poststroke depression in aged patients and effect on neural dysfunction of shuganjieyu capsule. Methods A total of 84 aged patients with mild and moderate ischemic poststroke depression were randomly assigned to the test group and the control group ( re = 42,each ). The test group was treated with shuganjieyu capsule (0.72 g, bid), and the control group was treated with citalopram tablet (20 mg, qd ) for 6 weeks. The therapeutic efficacy, adverse reactions and neurological dysfunction were evaluated at the beginning and by the end of 2-,4-,6-week after treatment by Hamilton Depression Scale( HAMD ), Hamilton Anxiety Scale( HAMA ), Clinical Global Impression( CGI ), Treatment Emergent Symptoms Scale( TESS ), and Chinese Scale of Clinical Neurologic Deficit ( CSS ), respectively. Results By the end of study, the efficacy of the test group and the control group was 69. 0% and 64. 3% , respectively ( P>0. 05 ). And the scores of HAMD and HAMA were significantly lower than those at the start( P<0. 05 ), and no statistically significant difference was found between two groups( P>0.05 ). The TESS was conspicuously fewer in the test group than that in the control group ( P<0. 01 ), while the efficacy index of which was remarkably superior than that of the control group ( P<0.01 ). By the 6th weekend,the CSS was significantly lower than that at the beginning and that in control group ( P<0.05 ). Conclusion Shuganjieyu capsule presents the similar effect as citalopram on treating mild and moderate poststroke depression in aged patients with less side effects and promotes neurological function recovery.关键词
舒肝解郁胶囊/西酞普兰/脑卒中,缺血性/抑郁症Key words
Shuganjieyu capsule/Citalopram/Cerebrovascular accident/Depression分类
医药卫生引用本文复制引用
苏伟,那万秋,李建华,杨剑虹,夏青春,关铁峰..舒肝解郁胶囊与西酞普兰治疗老年缺血性脑卒中后抑郁的疗效比较[J].医药导报,2012,31(3):322-325,4.
