医药导报2012，Vol.31Issue(4)：414-416,3.DOI:10.3870/yydb.2012.04.002
碧云喷雾剂对豚鼠变应性鼻炎的干预作用
Effect of Biyun Spray on Allergic Rhinitis in Guinea Pigs
摘要
Abstract
Objective To study the effects of Biyun spray on allergic rhinitis ( AR) induced by 2, 4-tolunen diisocyanate (TDI) in guinea pigs. Methods TDI was selected as sensibiligen and administered intranasally to develop the AR model. The experimental guinea pigs were randomly divided into 4 groups: control group, model control group, Biyun spray group, positive control (ketotifen fumarate) group. Corresponding volume of 0.9% sodium chloride solution was administered to the control and model control groups. In the Biyun spray group, Biyun spray was administered at a dose of 96 mg ? Kg"1 , which was twice the clinical equivalent dose. Ketotifen fumarate was administered to positive control group at a dose of 0. 07 mg ? Kg" . Symptoms were observed and the nasal symptom score of AR was determined. The pathological changes of nasal mucosa tissue were observed under a microscope. Eosinophilic granulocytes (EOS) and mast cells (MC) were counted. Results Among the control, model control, Biyun spray, and positive control groups, the nasal symptom scores of AR were decreased from (1.17± 0.63), (7.05±1.24), (7.56*1.05), (7.69±0.96) to (1. Ll±0. 54), (7.33±0.67), (4.92±0.96), (5. 14±0.77), respectively after the treatments. Biyun spray significantly decreased the nasal symptom score of AR (P<0. 01 ). Pathological changes of nasal mucosa tissue were improved obviously. Among the control, model control, Biyun spray, and positive control groups, the EOS number was (1.68±0. 85) , (9. 13±1.68) , (4. 51±2.25) and (3.59±1.77) , respectively; the MC number was (2.23±1.26), (21. 03±5. 03) , (14.05±6.88) and (13. 14±5. 41) , respectively; the degranulation MC number was (1.32±1.03), (13. 64±5. 47), (8.49±2.37) and (6.06±2.55), respectively. Biyun spray significantly improved the pathological changes of nasal mucosa with EOSs and MCs being decreased significantly (P<0.01). Conclusion Biyun sprayis effective in treating allergic rhinitis in guinea pigs.关键词
碧云喷雾剂/鼻炎,变应性/嗜酸性粒细胞/肥大细胞Key words
Biyun spray/ Rhinitis, allergic / Eosinophilic granulocyte/ Mast cell分类
医药卫生引用本文复制引用
贺卫和,王志琪..碧云喷雾剂对豚鼠变应性鼻炎的干预作用[J].医药导报,2012,31(4):414-416,3.基金项目
湖南省中医药科研项目基金(2010056) （2010056）
湖南省重点学科建设资助项目(1007) （1007）
