医药导报2012，Vol.31Issue(4)：497-499,3.DOI:10.3870/yydb.2012.04.032
气相色谱法测定檀香通脉胶囊中冰片与薄荷脑含量
Simultaneous Determination of Borneol and Menthol in Tanxiang Tongmai Capsule by Gas Chromatography
刘宇 1程璐2
作者信息
- 1. 华中科技大学同济医学院附属同济医院药学部,武汉,430030
- 2. 武汉市第一医院药剂科,430022
- 折叠
摘要
Abstract
Objective To establish gas chromatography ( GC) method for separating and determining both borneol and menthol in tanxiang tongmai capsule. Methods Naphthalene served as an internal standard, acetic ether as a solvent, 10% PEG-20M as separation, nitrogen as the carrier gas. Column temperature was set at 130℃ , and injector and detector temperature was 180℃. Sample size was 1 μL by using flame ionization detector. Results The linear ranges of borneol and menthol were 0.26-2.55 mg ? mL-1(r = 0. 999 9) and 0. 26 - 2. 62 mg ? mL-1(r = 0. 999 8) , respectively. Recovery rates of borneol and menthol were 97. 5 % (RSD = 1.77 % ) and 96. 81 % (RSD = 1.28 % ) , respectively. Conclusion This method is convenient, rapid, accurate and reproducible, and can be used for quality control of tanxiang tongmai capsule.关键词
檀香通脉胶囊/冰片/薄荷脑/色谱法,气相Key words
Tanxiang tongmai capsule/ Borneol/ Menthol/ Gas chromatography分类
医药卫生引用本文复制引用
刘宇,程璐..气相色谱法测定檀香通脉胶囊中冰片与薄荷脑含量[J].医药导报,2012,31(4):497-499,3.
