应用化学2011，Vol.28Issue(11)：1269-1273,5.DOI:10.3724/SP.J.1095.2011.00680
碱性水溶液中单6-氧-对甲苯磺酰-β-环糊精酯的非均相合成
Heterogeneous Synthesis of Mono 6-Deoxy-tosyl-β-cyclodextrin in Alkaline
摘要
Abstract
Employing heterogeneous reaction, 6-deoxy-tosyl-β-cyclodextrin(6-Ots-/3-CD) was prepared by the reaction of β-CD with p-toluenesulfonyl chloride at low temperature in sodium hydroxide aqueous solution. The compound has been characterized by means of UV-Vis, IR,1H NMR and 13C NMR spectroscopies. The mechanism of cyclodextrin mono tosylation was confirmed by 1H NMR. The effect of hydrolysis factors on product and the influence of reaction conditions on the yield were investigated. Under optimal reaction conditions molar ratio of reactant n(TsCl):n(CD) =4:1, alkali concentration 0. 75 mol/L, mass fraction of reactants 4. 7% , reaction temperature 0 °C and reaction time 5 h, a yield of 43. 4% can be obtained.关键词
非均相/氧-对甲苯磺酰基-β-环糊精/β-环糊精/对甲苯磺酰氯Key words
heterogeneous system/ deoxy-tosyl-β-cyclodextrin /β-cyclodextrin /β-toluenesulfonyl chloride分类
化学化工引用本文复制引用
王用良,冯茹森,郭拥军,吕鑫..碱性水溶液中单6-氧-对甲苯磺酰-β-环糊精酯的非均相合成[J].应用化学,2011,28(11):1269-1273,5.基金项目
国家科技重大专项(2008 ZX05024)资助项目 （2008 ZX05024）
