针刺研究2011，Vol.36Issue(5)：335-340,6.
电针配合冰片对小鼠血脑屏障通透性的影响
Effect of Electroacupuncture Combined with Intragastric Administration of Borneol on the Permeability of Blood-Brain Barrier in the Mouse
摘要
Abstract
in the borneol-0. 2 group (P<0. 05), suggesting a synergistic effect of EA and borneol. No significant differences were found a-mong the EA, borneol-0.2 and borneol-0. 4 groups in cerebral EB levels, among the control, EA, borneol-0. 2. Borneol-0. 4, bor-neol-0. 2 + EA, borneol-0. 4 + EA and verapamil groups in plasma Rh123 contents, and among the EA, borneol-0. 2, borneol-0. 4, borneol-0. 2 + EA, borneol-0. 4 + EA and verapamil groups in cerebral Rh 123 contents and Kp of BBB (P>0. 05). Results of the electron transmission microscope showed that the compact degree of the tight junction of BBB was decreased in the borneol-0. 2, borneol-0. 4, borneol-0. 2 + EA, borneol-0. 4 + EA groups but not in the EA group. Conclusion EA and gavage of borneol treatments may enhance the permeability of BBB for EB and Rh 123 and have a certain synergistic effect in mice. The effect of borneol may be closely with the inhibition of P-glycoprotein and the decrease of tight junction of BBB while the effect of EA treatment is probably related to the inhibition of P-glycoprotein only.关键词
电针/冰片/血脑屏障/P-糖蛋白/超微结构Key words
EA/ Borneol/ BBB/ P-glycoprotein/ Ultrastructure分类
医药卫生引用本文复制引用
喻斌,吕高红,孙永,林心,方泰惠..电针配合冰片对小鼠血脑屏障通透性的影响[J].针刺研究,2011,36(5):335-340,6.基金项目
国家自然科学基金青年基金(81001651) （81001651）
南京中医药大学针药结合省部共建教育部重点实验室开放课题(KJA 200905) （KJA 200905）
