针刺研究2011，Vol.36Issue(5)：357-360,4.
平衡针对腰椎神经根压迫模型大鼠血浆β-内啡肽、促肾上腺皮质激素的影响
Effects of Balance-acupuncture Stimulation of“Back Pain” and “Hip Pain”Points on Plasma β-endorphin and ACTH Contents in Rats with Lumbar Disc Herniation
摘要
Abstract
Objective To observe the effect of balance acupuncture on the thermal pain threshold and plasma β-endor-phin (p-EP) and adrenocorticotrophic hormone (ACTH) levels in lumbar disc herniation rats so as to research its mechanisms underlying improvement of lumbar disc protrusion. Methods A total of 120 male rats were randomly divided into blank control (control) group, model group. Sham-operation(sham)group, and acupuncture group (n = 30) which were further divided into 7-days (d) and 14-d subgroups. Rats in the acupuncture group were treated with balance acupuncture of "Back Pain" point (the midpoint between two eyes) and "Hip Pain"point (the midpoint between the acromial process and the axillary furrow). Thermal pain threshold was detected by using radiant heat detector. Plasma p-EP and ACTH levels were determined by radioimmunoassay. Results Compared with the control group and pre-operation and sham group, the thermal pain reaction was increased significantly in the model group (P<0. 05). In comparison with the model group, the thermal pain reaction was decreased obviously from day 10 after acupuncture treatment in the acupuncture group (P<0. 05). Compared to the control group, plasma p-EP contents on day 7 and 14 and ACTH level on day 14 in the model group were increased significantly (P<0. 05) .while in comparison with the model group, plasma P-EP contents on day 7 and 14 and ACTH level on day 14 in the acupuncture group were down-regulated markedly (P<0. 05). No significant difference were found between the control and sham groups in plasma P-EP contents and ACTH levels on day 7 and 14 (P>0. 05). Conclusion Balance acupuncture treatment can lower plasma ACTH level in lumbar disc herniation rats, which may contribute to its effect in easing lumbar disc herniation pain in clinic practice.关键词
平衡针/腰椎间盘突出症/针刺镇痛/促肾上腺皮质激素/β-内啡肽Key words
Balance acupuncture/ Lumbar disc herniation/ Acupuncture analgesia/ Plasma p-EP/ Plasma ACTH分类
医药卫生引用本文复制引用
马文珠,张艺萌,袁红,王文远..平衡针对腰椎神经根压迫模型大鼠血浆β-内啡肽、促肾上腺皮质激素的影响[J].针刺研究,2011,36(5):357-360,4.基金项目
国家"973"课题平衡针疗法治疗颈肩腰腿痛的基础研究(No:2007 CB 512704) （No:2007 CB 512704）
