针刺研究2011，Vol.36Issue(5)：366-372,7.
运用fMRI观察电针关元及中脘穴相对特异性的脑功能网络
Electroacupuncture at Guanyuan (CV 4) and Zhongwan (CV 12) Modulates Functional Connectivitv of the Brain Network in Healthy Volunteers
摘要
Abstract
Objective To observe the specific brain effects of electroacupuncture (EA) stimulation of Guanyuan (CV 4) and Zhongwan (CV 12). Methods Twenty-one healthy volunteers were recruited in the present study. Two silver filiform needles were separately inserted into Guanyuan (CV 4) or Zhongwan (CV 12), and manipulated with uniform reducing-reinforcing method to induce "Deqi". fMRI scan was performed before needling, during needle retention, EA stimulation, and post-EA. Data of fMRI was analyzed by using software SPM 2. The volunteer subjective needling sensations were recorded. The activation, de-activation, short-distance and long-distance functional connectivity maps of different cerebral regions were analyzed by using whole brain correlation analysis. Results Comparison between the two acupoints showed that fullness feeling was stronger in CV 4 than in CV 12. EA at CV 4 and CV 12 induced a similar stronger and prevalent deactivation in the ventral medial prefrontal cortex and the anterior cingulated cortex (ACC). The deactivation of the ACC was stronger in the CV 4 group than in the CV 12 group. The default BOLD mode of the brain at rest was modified by needle retention and EA, respectively. The short-distancefunctional connection brain network was significantly changed after EA. Interestingly. The ventral medial prefrontal cortex and an-teroinferior portion of the anterior cingulate cortex in the limbic-paralimbic-neocortical network (LPNN) were involved in the instant post-effects of EA. Relatively smaller differences in the brain functional activity and short-distance functional connectivity were found between these two acupoints. Conclusion EA of CV 4 and CV 12 can modulate short-distance functional connectivity of the LPNN, and have fewer differences in inducing needling sensation and deactivation of ACC, etc.关键词
电针/fMRI/脑功能连接/穴位特异性/关元穴/中脘穴Key words
Electroacupuncture/ fMRI/ Brain functional connectivity/ Acupoint specificity/ GuanyuanCCV 4)/ Zhongwan (CV 12)分类
医药卫生引用本文复制引用
方继良,宋明,刘保延,朱兵,洪洋,王小玲,刘河生,王寅,刘军,王雷,薛超,周科华..运用fMRI观察电针关元及中脘穴相对特异性的脑功能网络[J].针刺研究,2011,36(5):366-372,7.基金项目
美国国立卫生研究院替代医学中心(NIH/NCCAM:1 F 05 AT 003022-01-04) （NIH/NCCAM:1 F 05 AT 003022-01-04）
国家自然科学基金面上课题(No.30870668) （No.30870668）
