中国当代儿科杂志2012，Vol.14Issue(1)：42-44,3.
先天性心脏病患儿血浆脑钠肽水平与左心功能的关系
Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease
摘要
Abstract
Objective To study the correlation between the blood serum brain natriuretic peptide ( BNP) level and the left cardiac function in children with congenital heart disease ( CHD) . Methods The clinical data of 41 CHD children were retrospectively analyzed. Patients were divided into two groups based on the existence of congestive heart failure ( CHF) : CHD + CHF ( n = 21 ) and CHD alone ( n = 20). The blood serum BNP level was determined using chemiluminescence immunoassay, and the left ventricular ejection fraction ( LVEF ) was measured with echocardiogram. Results The serum BNP level was 1353 pg/mL (range: 926-2978) in the CHD + CHF group, which was significantly higher than in the CHD alone group [ 149 pg/mL ( range; 75-242) ] ( P <0. 01). The LVEF was 60% ( range: 53% -65% ) in the CHD + CHF group, which was significantly lower than in the CHD alone group [68% ( range: 64% -72% ) ] ( P < 0. 01). The serum BNP level showed a negative correlation with the LVEF level ( r = - 0. 652, P < 0. 01 ) . Conclusions The blood serum BNP level is related to the cardiac function. For children with severe CHD + CHF, serum BNP level can be used as a sensitive indicator for evaluating cardiac function damage.关键词
先天性心脏病/脑钠肽/左室射血分数/心力衰竭/儿童Key words
Congenital heart disease/ Brain natriuretic peptide/ Left ventricular ejection fraction/ Heart failure/ Child分类
医药卫生引用本文复制引用
张鹤,李玖军..先天性心脏病患儿血浆脑钠肽水平与左心功能的关系[J].中国当代儿科杂志,2012,14(1):42-44,3.基金项目
2009年辽宁省自然科学基金项目(项目编号20092099) （项目编号20092099）
2009年辽宁省教育厅基金项目(项目编号2009A782). （项目编号2009A782）
