中国当代儿科杂志2012，Vol.14Issue(2)：120-123,4.
TIM-4基因多态性与儿童哮喘的关系
Relationship between TIM-4 polymorphism and childhood asthma
摘要
Abstract
Objective To elucidate whether the polymorphism of asthma immune regulator gene TIM-4 is associated with the risk of childhood allergic asthma in the southwest region of China. Methods TIM-4 gene promoter region RS6882076 and intron RS4704727 were studied. PCR-RFLP was used to test the genotypes of two polymorphism loci among 579 cases ( average 7. 2 years old) of asthma and 524 controls ( average 7. 6 years old) in a case-control study. Results There were significant differences in the frequency of gene types at RS4704727 site between the asthma and the control groups (P<0.01). The results of PCR-RFLP showed that the polyporphisms of RS6882076 and RS4704727 in TIM-4 gene were present in this study population. The frequency of T allele at the RS4704727 site in the asthma group was significantly lower than that in the control group ( OR = 1. 603; 95% CI 1. 304-1. 971; P < 0. 01 ). There were no significant differences in the frequencies of gene types and allele at RS6882076 site between the two groups ( P > 0. 05). Conclusions RS4704727 polymorphism of TIM-4 gene may be associated with childhood asthma, providing a better understanding of the pathogenesis of childhood asthma in the Southwest region of China.关键词
哮喘/单核苷酸多态性/TIM-4/儿童Key words
Asthma/ Single nucleotide polymorphism/ TIM-4/ Child分类
医药卫生引用本文复制引用
陈建平,赵婉莹,何念海,和水祥,王刚,汪万军..TIM-4基因多态性与儿童哮喘的关系[J].中国当代儿科杂志,2012,14(2):120-123,4.基金项目
国家自然科学基金项目(No.30600686 （）
重庆市自然科学基因(CSTC,2007 BB5062). （CSTC,2007 BB5062）
