中国当代儿科杂志2012，Vol.14Issue(2)：131-133,3.
儿童药物性肝损害的临床研究
Clinical features of drug-induced liver injury in children
朱欣欣 1朱渝 1万朝敏1
作者信息
- 1. 四川大学华西第二医院儿科,四川 成都 610041
- 折叠
摘要
Abstract
Objective To study the clinical features of drug-induced liver injury in children. Methods The clinical data of the hospitalized children with drug-induced liver injury over 5 years were retrospectively reviewed. Results Of 641 cases of hospitalized children with liver injury, there were 64 cases ( 10% ) of drug-induced liver injury. Hepatocellular injury was the most common type of drug-induced liver injury (81%). The major drugs causing drug-induced liver injury included chemotherapy drugs, antibiotics and anti-tuberculosis drugs. Rash ( 16% ) , gastrointestinal reaction ( 15% ) , fever (14% ) and liver intumescence (12% ) were common clinical symptoms. A part of patients with drug-induced liver injury (11% ) had no symptoms and signs. Conclusions Drug-induced liver injury is one of the common causes of liver damage in hospitalized children. Some children with drug-induced liver injury have no symptoms and signs. Hepatocellular injury is a major type of drug-induced liver injury in children, resulting less severe liver damage.关键词
药物性肝损害/临床特点/儿童Key words
Drug-induced liver injury/ Clinical feature/ Child分类
医药卫生引用本文复制引用
朱欣欣,朱渝,万朝敏..儿童药物性肝损害的临床研究[J].中国当代儿科杂志,2012,14(2):131-133,3.
