中国动脉硬化杂志2012，Vol.20Issue(1)：1-5,5.
生物机械力对血管重构的影响及机制
The Effects of Biomechanical Stress on Vascular Remodeling and Its Mechanism
摘要
Abstract
Biumechuiucal stress existing in the human body plays a pivotal role in the progression of human develop-menl, growth or diseases. But how the mechanical stress acts ?n the organism leading to a series of changed pathophysiol-ogy is an attractive issue. Significantly advanced progresses concerning mechanical stress-related tissue or tell remodeling have l-weti made in the recent years, especially in cardiovascular area. For instance, we already realized that mechanical stress resulted From Increased blood pressure (e. G. Hypertension) or abnormal hemodynamics due to altered angioarchitec-lure (e- g. Atherosclerosis) muy not only he an initiator bul also he a terminator in ihe development, maintenance or promotion of the cardiovascular diseases. Thus, mechanical stress a& an independent risk factor has more obviously deleterious effecis on changed structure and function of blood vessels compared with most of other growth factors and active polypep-lides. This review will focus on the current advances from our and other investigators regarding the effects of mechanical stress on iwrmal structure, function, and diseases of blood vessels.关键词
生物机械力/信号转导/血管疾病Key words
Biomechankal Stress/ Signal Transduction/ Vascular Disease分类
医药卫生引用本文复制引用
李朝红..生物机械力对血管重构的影响及机制[J].中国动脉硬化杂志,2012,20(1):1-5,5.基金项目
国家自然科学基金(30570762,30871023,81070124) （30570762,30871023,81070124）
广东省自然科学基金(8151008901000044) （8151008901000044）
高等学校博士学科点专项科研基金(20090171110049) （20090171110049）
