中国康复理论与实践2011，Vol.17Issue(11)：1025-1027,3.
28醇对6-羟基多巴胺致帕金森病大鼠模型行为学的改善作用
Effects of Octacosanol on Behavioral Impairments in Rats with Parkinson's Disease Induced by 6-hydroxydopamine
摘要
Abstract
Objective To explore the effects of octacosanol on the behavioral impairments in rats with Parkinson's disease (PD) induced by 6-hydroxydopamine (6-OHDA). Methods The SD rats were divided into the control group (n=15), the model group (n=15), the low dose group (n=12), the medium dose group (n=12) and the high dose group (n=12). 6-OHDA was stereotactically injected into the right striatum of the rats at 2 sites to produce PD models. The treatment groups received octacosanol with the dose of 17.5 mg/kg, 35 mg/kg or 70 mg/kg for 2 weeks. They were tested with apomorphine-induced rotation test, the modified Morris Water Maze, and rotarod test. Results The con-tralateral rotation in 30 min and escape latency were less in the medium and high dose groups than in the model group (.P<0.05); the latency and total time in the rotarod test were significantly less in all the treatment groups than in the model group (f<0.01). Conclusion Octacosanol can decrease the impaired behaviors of rats with PD induced by 6-OHDA.关键词
帕金森病/28醇/6-羟基多巴胺/行为学/大鼠Key words
Parkinson's disease/octacosanol/6-hydroxydopamine/behavioral tests/rats分类
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王涛,刘亚静,刘雁勇,杨楠,纪超,陈彪,左萍萍..28醇对6-羟基多巴胺致帕金森病大鼠模型行为学的改善作用[J].中国康复理论与实践,2011,17(11):1025-1027,3.基金项目
国家973基金项目(2010CB934002:2011CB504101 （）
2011CBA00408) （）
2.国家自然科学基金项目(81050025). （81050025）
