中国康复理论与实践2011，Vol.17Issue(11)：1031-1034,4.
CD14mRNA的表达在急性脑出血肠-肝轴紊乱中的作用及星蒌承气汤的干预研究
Expression of CD14 mRNA in Intestine-liver Axis Disorder during Acute Cerebral Hemorrhage and Effects of Xinglouchengqi Decoction
摘要
Abstract
Objective To investigate the influence of CD14 on lipopolysaccharide (LPS) signal transduction pathway during the hepatic stress injury in acute cerebral hemorrhage, and explore the protection mechanism of Xinglouchengqi decoction. Methods The model of acute cerebral hemorrhage was established with injection of collagenase Ⅶ into internal capsule of cerebrum. The rats were randomly divided into blank control group, cerebral hemorrhage group, syndrome of phledm-heat and fu-organ excess model group and Xinglouchengqi group. Each group was divided into 3 time sub-groups (24 h, 48 h, 72 h). The expression of CD14 mRNA in liver tissue and mesenteric lymph nodes were observed by real-time quantitative polymerase chain reaction. Results The expression of CD14 mRNA was higher in model-group than blank control group (P<0.05). Xinglouchengqi decoction could reduce liver pathological injury significantly. Conclusion CDT4 plays an important role in endotoxin-mediated liver injury. Xinglouchengqi decoction can protect the liver in cerebral hemorrhage.关键词
白细胞分化抗原14/急性脑出血/应激性肝损害/痰热腑实证Key words
cluster of differentiation 14/acute cerebral hemorrhage/hepatic stress injury/syndrome of phledm-heat and fu-organ excess分类
医药卫生引用本文复制引用
赵海滨,唐杰,马立华,王威,王帅,张秀静..CD14mRNA的表达在急性脑出血肠-肝轴紊乱中的作用及星蒌承气汤的干预研究[J].中国康复理论与实践,2011,17(11):1031-1034,4.基金项目
国家自然科学基金(81072772). （81072772）
