中国康复理论与实践2012，Vol.18Issue(1)：12-14,3.DOI:10.3969/j.issn.1006-9771.2012.01.005
运动对老龄脑缺血再灌注大鼠空间学习记忆能力的影响及其机制
Effects of Exercise on Learning-memory of Space in Aged Rats after Cerebral Ischemia-reperfusion
摘要
Abstract
Objective To study the effects and mechanism of exercise on learning-memory of space and in aged rats after cerebral isch-emia-reperfusion. Methods 20 SD rats at the age of 20 months with cerebral ischemia-reperfusion were randomly divided into 2 groups. The experimental group (n=10) received regularly exercise, while the control group (n=10) exercised freely. Morris water maze was tested 1 week after exercise, and the brain-derived neurotrophic factor (BDNF) mRNA expression on the ischemic side of the hippocampus were detected. Results The latency in the 2nd round decreased (P<0.05) and the path line on the platform increased (P<0.05) in the experimental group in Morris water maze test (P<0.05), while the BDNF mRNA increased (,P<0.01), compared with control group. Conclusion Regular exercise can improve space learning-memory ability of cerebral ischemia-reperfusion aged rats, which may associate with increased BDNF mRNA expression in hippocampus.关键词
缺血再灌注/运动/空间学习记忆/大鼠/老龄Key words
ischemia-reperfusion/ exercise/ space learning-memory/ rats/ aged分类
医药卫生引用本文复制引用
陈秀恩,郑洁皎,梁贞文..运动对老龄脑缺血再灌注大鼠空间学习记忆能力的影响及其机制[J].中国康复理论与实践,2012,18(1):12-14,3.基金项目
上海市科委基金项目(06JC14027). （06JC14027）
