中国康复理论与实践2012，Vol.18Issue(1)：47-52,6.DOI:10.3969/j.issn.1006-9771.2012.01.015
丰富环境与脑卒中康复
Enriched Environment and Stroke Rehabilitation (review)
摘要
Abstract
An enriched environment refers to conditions that facilitate sensory, cognitive, motor, and social stimulation. Behavioural, cellular and molecular studies have revealed significant effects of enriched environments on rodents and other species. Post-ischemic housing in an enriched environment improves functional outcome, modifies gene activation, induces alterations in the expression of N-meth-yl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits, increases dendrite branching and number of dendritic spine in pyramidal neurons in layers Ⅱ /Ⅲ in the contra-lateral cortex, induces structural changes in synap-tic junctions. Furthermore, it alters lesion-induced progenitor cell differentiation and interacts with necrotic grafting. The idea of environmental enrichment has been applied to clinical stroke rehabilitation and is getting more and more attention. This review will summarize experimental effects of enriched environment on post-ischemic rehabilitation and the clinical application of enriched environment in stroke rehabilitation.关键词
丰富环境/脑卒中/脑梗死/基因活化/树突棘/突触结构/祖细胞分化/神经移植Key words
enriched environment/ stroke/ cerebral infarction/ gene activation/ dendritic spine/ synaptic junction/ progenitor cell differentiation/ neocortic grafting分类
医药卫生引用本文复制引用
李娴,谢斌..丰富环境与脑卒中康复[J].中国康复理论与实践,2012,18(1):47-52,6.基金项目
北京市科委重大项目(D08050700330000) （D08050700330000）
