中国康复理论与实践2012，Vol.18Issue(3)：226-229,4.DOI:10.3969/j.issn.1006-9771.2012.03.009
药物和行为干预对缺血缺氧性脑损伤大鼠功能恢复的影响
Effects of Neurotrophics and Rehabilitation on Neural Function after Hypoxic-ischemic Brain Injury in Rats
摘要
Abstract
Objective To investigate the effects of neurotrophics and rehabilitation on the neural function recovery after the hypox-ic-ischemic brain injury in rats. Methods Model rats of hypoxic-ischemic brain injury were given monosialotetrahexosylganglioside sodium (GM1, n=8), mouse nerve growth factor (NGF, n=8), both drugs (n=8), rehabilitation (n=8), both drugs+rehabilitation (n=8) and control (no intervention, n=8). The other 7 rats was as sham group. They were assessed with hanging and inclined plane test when 30 days old. Results In the factorial design, main effect of GM1 was significant (P<0.05) but NGF (P>0.05) in hanging test; while both were significant in inclined plane test. The interaction was not significant (P>0.05) in both tests. The main effects of drugs and rehabilitation were significant (P< 0.05), as well as the interaction (P<0.05) in both tests. Conclusion GM1 may significantly improve muscle strength, voluntary movement, balance and coordination functions, and NGF may improve the balance and coordination functions. No interaction is found when combined with the two therapies. Rehabilitation may significantly improve muscle strength, voluntary movement, coordination and balance, and synergy effects can be gained when combined with the drugs.关键词
缺氧缺血性脑损伤/神经可塑性/神经营养因子/康复Key words
hypoxic-ischemic brain injury/neural plasticity/neurotrophic factors/rehabilitation分类
医药卫生引用本文复制引用
侯梅,杨会娟,姜艳平..药物和行为干预对缺血缺氧性脑损伤大鼠功能恢复的影响[J].中国康复理论与实践,2012,18(3):226-229,4.基金项目
青岛市科技发展计划项目(07-2-1-16-ns). （07-2-1-16-ns）
