中国康复理论与实践2012，Vol.18Issue(3)：236-238,3.DOI:10.3969/j.issn.1006-9771.2012.03.012
舒郁宁心汤对抑郁大鼠海马Bcl-2和Bax 表达的影响
Effect of Shuyuningxin Decoction on the Expression of Bcl-2 and Bax in Hippocampus of Chronic Stress Depression Rats
摘要
Abstract
Objective To investigate the effect of Shuyuningxin decoction on the expression of Bcl-2 and Bax in hippocampus of chronic stress depression rats. Methods 60 SD rats were randomly divided into control group, model group, fluoxetine group, high dose of Shuyuningxin decoction group, middle dose of Shuyuningxin decoction group and low dose of Shuyuningxin decoction group. All the groups were given the chronic unpredicted mild stress for 21 d to induce depression models except the control group. Then they were administrated their drugs for 21 d. The level of Bcl-2 and Bax in hippocampus were investigated with immunohistochemistry technique. Results Compared with the control group, the level of Bax increased and Bcl-2 decreased in the model group (P<0.05). Compared with model group, the level of Bax decreased and Bcl-2 increased in the middle dose of Shuyuningxin decoction group, high dose of Shuyuningxin decoction group and the fluoxetine group (P<0.05). Conclusion The anti-depression effect of Shuyuningxin decoction may be associated with the expression of Bax and Bcl-2.关键词
舒郁宁心汤/抑郁/Bcl-2/BaxKey words
Shuyuningxin decoction/depression/Bcl-2/Bax分类
医药卫生引用本文复制引用
黄泉智,许成勇,孙志高,杨阳,胡亚卓,陈利平,王发渭..舒郁宁心汤对抑郁大鼠海马Bcl-2和Bax 表达的影响[J].中国康复理论与实践,2012,18(3):236-238,3.基金项目
1.北京市科技计划基金课题(Z090507017709030) （Z090507017709030）
2.军队十二五攻关课题(CWS11J67). （CWS11J67）
