中国临床药理学与治疗学2011，Vol.16Issue(12)：1374-1378,5.
Ⅰ组代谢型谷氨酸受体激活调制脊髓运动神经元的下行激活
Activation of group Ⅰ metabotropic glutamate receptors modulates descending activation of spinal cord motoneurons
摘要
Abstract
AIM: To evaluate the modulatory action of group I metabotropic glutaraate receptors (mGluRs) on descending activation of spinal cord motoneurons (MNs) in vitro. METHODS; The intracellular recordings were made in MNs of spinal cord slices isolated from neonatal rats (7-14 days old) , and excitatory postsynap-tic potential (EPSP) was evoked by ipsilateral ventrolateral funiculus (iVLF) stimulation, I. e. iVLF-EPSP. By superfusion of (S)-3, 5-di-hydroxyphenylglycine hydrate (DHPG) , an agonist of group I mGluRs, the modulatory action was observed on the MN membrane electrical properties, as well as on the iVLF-EPSP. RESULTS: Application of DHPG (5 pmol/L) significantly depolarized the motoneuron membrane(n = 7, P<0. 01), reduced time constant (n = 7, P<0. 05), and extended the half-width of the spike potential (n = 5, P<C0. 05). The amplitude of iVLF-EPSPs in 7 tested MNs was re-versibly and concentration-dependently suppressed by superfusion of DHPG (5 - 10 Fmol/L,P<0. 01). CONCLUSION: Activation of group I mGluRs by DHPG may inhibit the descending activation of spinal cord MNs in vitro. Drate(DHPG)关键词
运动神经元/脊髓/代谢型谷氨酸受体/下行激活/(S)-3,5-二-羟基苯基甘氨酸Key words
Motoneuron/Spinal cord/Metabotropic glutamate receptor/Descending activation/(S)-3, 5-dihydroxyphenylglycine hy-分类
医药卫生引用本文复制引用
郑勇,汪萌芽..Ⅰ组代谢型谷氨酸受体激活调制脊髓运动神经元的下行激活[J].中国临床药理学与治疗学,2011,16(12):1374-1378,5.基金项目
安徽省自然科学基金(090413084) （090413084）
